Exactly defined molecular weight poly(ethylene glycol) allows for facile identification of PEGylation sites on proteins
We are thrilled to announce the publication of our new research paper titled “Exactly defined molecular weight poly(ethylene glycol) allows for facile identification of PEGylation sites on proteins” in Nature Communications!
Diagram illustrating the differences between conventional PEGylation and PEGylation defined in this publication. Using Exactmer’s defined molecular weight PEG synthesis enables for easy identification of PEGylated regions within a protein using relatively straightforward techniques.
In this study, we propose a chromatography-free synthesis process to produce defined PEGs with a molecular weight of 5kDa.
This breakthrough approach enables the use of precisely defined molecular weight poly(ethylene glycol) to address current batch-to-batch variations and unpredictable impurities in PEGylated drugs — an essential consideration for advancing biopharmaceutical development.
Our findings could transform how PEGylation, a key method to improve protein stability and therapeutic efficacy, is studied and applied in drug development.
We invite you to read the full paper and explore how Exactmer’s innovation could impact the future of drug design and protein synthesis. Find out more about how our findings on PEG synthesis can help you by visiting Our Services – Exactmer.
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