Transforming Oligonucleotide Manufacturing Through Membrane Innovation
Exact‑10™, Exact‑01™ and Exact‑20™ are Exactmer's organic solvent nanofiltration (OSN) membranes, each tuned to a different molecular weight cut‑off for a different stage of oligonucleotide synthesis and other pharmaceutical manufacturing applications.
Where each membrane fits
Exact‑10™
A key component of our Nanostar Sieving® platform for sequence-defined polymers. Designed for iterative liquid-phase synthesis, it combines high selectivity with excellent organic solvent stability, purifying efficiently at every synthesis cycle for high purity polymers.
Exact‑01™
High solute rejection for solvent purification and recycling, cutting solvent costs, simplifying handling and minimising waste. Avoiding energy-intensive distillation improves pharmaceutical sustainability. With our Nanostar Hub enabling more concentrated reactions, our membranes reduce solvent use in oligonucleotide synthesis, particularly for short oligo fragments (5-10mer) in convergent synthesis.
Exact‑20™
Streamlines downstream purification of oligonucleotides and complex molecules. Optimised for Tangential Flow Filtration (TFF) in aqueous‑organic solvent mixtures, for solvent exchange, impurity removal and concentration of reaction mixtures and chromatography eluents. Bespoke membrane modification ensures low fouling and high selectivity, for efficient, scalable purification and improved yield.
Exact‑10™ is a key component of Exactmer's Nanostar Sieving® platform for the synthesis of sequence-defined polymers.
One membrane, every scale
From early-stage evaluation to full manufacturing, our membranes are available in formats built for each stage of development.
Flat Sheets
Compact, low-volume format ideal for initial screening, process development and early-stage evaluation work before committing to larger-scale trials.
Spiral Wound Modules (SWMs)
Our membranes rolled into a high-density, industrially proven format built for medicines manufacturing and large-scale, continuous processing.
What is a Spiral Wound Module (SWM)?
A Spiral Wound Module is built from multiple membrane sheets, each separated by two types of spacer: a feed spacer, which keeps the sheets apart and helps material flow evenly across the membrane surface, and a permeate spacer, which channels the filtered liquid away. These layers are glued together into “leaves” and rolled around a central tube to form the finished module.
more membrane area than a crossflow cell.
Rolling the membrane this way packs far more surface into a small space, taking a process from lab scale to full production. This scale-up approach is proven and widely used, including across the desalination industry. We apply the same fabrication process to build Nanostar Sieving® membranes as SWMs, ready for commercial manufacturing.
How OSN separation works
Applied pressure drives the process across the membrane, separating molecules purely by size. Because separation is based on size, the same mechanism underpins Exactmer's entire membrane range, from synthesis to purification to solvent recovery.
Large molecules (the growing oligo) are retained by the membrane.
Small molecules (monomers and reaction debris) permeate through.
Not sure which membrane fits your process?
Talk to our team about evaluation programmes, technical batches, and partnership routes across the Exact range.
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