Exactmer is delighted to welcome to Alnylam Pharmaceuticals as a partner to the collaboration with the Medicines Manufacturing Innovation Centre, revolutionising oligonucleotide manufacturing. Together with CPI, AstraZeneca, and Novartis, we’re working together to overcome barriers to the scalable, affordable, and sustainable manufacture of oligonucleotides.
See the full press release on the CPI website.
In the latest issue of Chemistry Today, Andrew Livingston and Katie Murray discuss the challenges involved with oligonucleotide manufacturing, and the role Nanostar Sieving can play in overcoming them.
Abstract
Oligonucleotides, which have already shown success in the treatment of rare diseases, are now being used to treat conditions with much larger patient populations. However, limitations associated with the current state-of-the-art solid-phase manufacturing technology – namely high costs and low capacity – inhibit their true potential. Despite this, oligonucleotide-based drugs are still moving through the R&D pipeline, but their progress will be hindered without an overhaul of the current manufacturing process. An exciting academic, government and industry collaboration is investigating the potential of a novel liquid-phase synthesis technique. This technique – referred to as Nanostar Sieving – circumvents many of the limitations associated with solid-phase oligonucleotide manufacturing, offering a more cost-effective and environmentally sustainable method of manufacturing oligonucleotides at a larger scale.
Read the full article here:
Exactmer is thrilled to announce a collaboration with AstraZeneca, Novartis, CPI and UK Research and Innovation aimed to revolutionise oligonucleotide medicines manufacturing.
Oligonucleotide drugs work by interfering with how genes are expressed and are now being explored to treat diseases affecting large patient populations, however their use is currently limited by inefficient manufacturing processes. This collaboration, known as Grand Challenge 3, at the Medicines Manufacturing Innovation Centre, aims to develop a cost effective, sustainable and scalable manufacturing method for oligonucleotide medicines. Inclisiran, an oligonucleotide drug from Novartis, would be the first medicine to be manufactured at scale as a result of this collaboration. AstraZeneca has a large pipeline of oligonucleotide therapies which will also benefit from the results of this collaboration.
Exactmer will lead the initial phase of the project focusing on both the development of scale-up strategies for liquid phase processes and on a proof-of-concept programme. The collaboration will utilise Nanostar Sieving technology to enhance the efficiency and yield of oligonucleotide manufacturing processes and reduce the manufacturing costs, enhancing the potential for large-scale manufacturing of oligonucleotide drugs.
Read the full press release on the CPI website.
